Research Update
نویسندگان
چکیده
Heavy alcohol consumption over long periods of time can result in severe liver damage, including death of liver cells (i.e., hepatocytes). Two mechanisms— apoptosis and necrosis—can contribute to hepatocyte death. In apoptosis, the affected cell actively participates in the cell death process, whereas in necrosis the cell death occurs in response to adverse conditions in the cell’s environment. Numerous factors that may contribute to the initiation of hepatocyte apoptosis are affected by alcohol consumption. These factors include the enzyme cytochrome P450 2E1 (i.e., CYP2E1), small molecules (i.e., cytokines) involved in cell communication, oxidative stress, and changes in iron metabolism. Similarly, alcohol consumption can influence several factors believed to be involved in hepatocyte necrosis, including depletion of the energy-storing molecule adenosine-triphosphate, reduced oxygen levels (i.e., hypoxia) in the liver, oxidative stress, and bacterial molecules called endotoxins.
منابع مشابه
O21: Update and Future Directions in Poststroke Epilepsy
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملA Formal Petri Net Based Model for Antivirus Update Agent System
In this paper, a formal model for antivirus update agent system is presented based on mobile agent technology and predicate/transition Petri nets. The mobile agent system contains two mobile agents called DCA and UNA. It sends out agents to update antivirus on client computers in a network. Each agent takes on a specified responsibility. First, DCA roams through the network and check the last d...
متن کاملA Formal Petri Net Based Model for Antivirus Update Agent System
In this paper, a formal model for antivirus update agent system is presented based on mobile agent technology and predicate/transition Petri nets. The mobile agent system contains two mobile agents called DCA and UNA. It sends out agents to update antivirus on client computers in a network. Each agent takes on a specified responsibility. First, DCA roams through the network and check the last d...
متن کاملA Review of Alcohol-Related Harms: A Recent Update
In the early decades of the 20th century, discussions regarding alcohol were dominantly directed toward itstherapeutic uses, but authorities now state that any level of alcohol consumption poses negative effects onhealth. Over recent months, increased attention has been devoted to disease burdens attributable to alcoholuse worldwide. As more...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2000